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Article

Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2016

Schweizer Ulrich, Fradejas-Villar Noelia

Abstract excerpt

Selenocysteine is the 21st proteinogenic amino acid in mammals. The human genome contains 25 genes encoding selenoproteins, and their significance for human health is increasingly recognized through the identification of patients with inborn errors in selenoprotein biosynthetic factors or in individual selenoproteins. Mutations in selenoprotein N (SEPN1) lead to a spectrum of disorders collectively called...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27473727
DOI: 10.1096/fj.201600424

Genes

SECISBP2
GPX4
SEPSECS
TXNRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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