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Article

Molecular study of a new family with hereditary renal cell carcinoma and a translocation t(3;8)(p13;q24.1).

Human genetics - 1 Feb 2003

Meléndez Bárbara, Rodríguez-Perales Sandra, Martínez-Delgado Beatriz, Otero Ignacio, Robledo Mercedes, Martínez-Ramírez Angel, Ruiz-Llorente Sergio, Urioste Miguel, Cigudosa Juan Cruz, Benítez Javier

Abstract excerpt

An alternative model has been proposed for the development of clear-cell renal cell carcinoma (RCC) in families where chromosome 3 translocations segregate with the disease. In this model, the existence of a translocation involving chromosome 3 would favour the non-disjunctional loss of the derivative chromosome carrying the 3p segment. Additionally, subsequent somatic mutations in the VLH gene, located in...

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Share to Adenocarcinoma, Clear Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12522559
DOI: 10.1007/s00439-002-0848-6

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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