Article
Analysis of multiple renal cell adenomas and carcinomas suggests allelic loss at 3p21 to be a prerequisite for malignant development.
Genes, chromosomes & cancer - 1 Aug 1997
van den Berg A, Dijkhuizen T, Draaijers T G, Hulsbeek M M, Maher E R, van den Berg E, Störkel S, Buys C H
Abstract excerpt
Multiple renal cell tumours from three unrelated patients have been analysed for loss of heterozygosity of 3p, mutation of VHL, and chromosome 7 and 17 imbalances. Loss of 3p alleles is characteristic for clear cell type tumours and the combination of +7, +17 for chromophilic cell type tumours. Thus, we could classify adenomas and carcinomas of the three patients according to the genomic patterns of the tumours....
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