Article
Population-based survey of cancer risks in chromosome 3 translocation carriers.
Genes, chromosomes & cancer - 1 Jan 2010
Woodward Emma R, Skytte Anne-Bine, Cruger Dorthe G, Maher Eamonn R
Abstract excerpt
Familial renal cell carcinoma (RCC) is genetically heterogeneous and may be associated with germline mutations in a number of genes. Twelve different constitutional translocations involving chromosome 3 have also been described in association with inherited RCC. In some families the lifetime risk of RCC in chromosome 3 translocation carriers has been estimated to be more than 80%; however the cancer risks in...
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