Article
TaqMan systems for genotyping of disease-related polymorphisms present in the gene encoding apolipoprotein E.
Clinical chemistry and laboratory medicine - 1 Nov 2002
Koch Werner, Ehrenhaft Angela, Griesser Korinna, Pfeufer Arne, Müller Jakob, Schömig Albert, Kastrati Adnan
Abstract excerpt
Polymorphisms of the gene encoding apolipoprotein E have been implicated in the pathogenesis of peripheral and coronary artery disease and neurodegenerative disorders such as sporadic and late-onset familial forms of Alzheimer's disease. We have developed TaqMan assay systems for the single nucleotide polymorphisms -219G/T, located in the promoter of the apolipoprotein E gene, 113G/C, present in the...
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