Article
Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2003
Hibino H, Pironkova R, Onwumere O, Rousset M, Charnet P, Hudspeth A J, Lesage F
Abstract excerpt
The beta subunits of voltage-gated Ca(2+) channels are known to be regulators of the channels' gating properties. Here we report a striking additional function of a beta subunit. Screening of chicken cochlear and brain cDNA libraries identified beta(4c), a short splice variant of the beta(4) subunit. Although beta(4c) occurs together with the longer isoforms beta(4a) or beta(4b) in the brain, eye, heart, and...
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