Article
Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation.
Channels (Austin, Tex.) - 1 Jan 2000
Ronjat Michel, Kiyonaka Shigeki, Barbado Maud, De Waard Michel, Mori Yasuo
Abstract excerpt
The pore-forming subunit of voltage-gated calcium channels is associated to auxiliary subunits among which the cytoplasmic β subunit. The different isoforms of this subunit control both the plasma membrane targeting and the biophysical properties of the channel moiety. In a recent study, we demonstrated that the Cacnb4 (β 4) isoform is at the center of a new signaling pathway that connects neuronal excitability...
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