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Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells.

Journal of proteome research - 6 Apr 2018

Tomin Tamara, Fritz Katarina, Gindlhuber Juergen, Waldherr Linda, Pucher Bettina, Thallinger Gerhard G, Nomura Daniel K, Schittmayer Matthias, Birner-Gruenberger Ruth

Abstract excerpt

Adipose triglyceride lipase (ATGL) catalyzes the rate limiting step in triacylglycerol breakdown in adipocytes but is expressed in most tissues. The enzyme was shown to be lost in many human tumors, and its loss may play a role in early stages of cancer development. Here, we report that loss of ATGL supports a more-aggressive cancer phenotype in a model system in which ATGL was deleted in A549 lung cancer cells...

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PMID: 29457907
DOI: 10.1021/acs.jproteome.7b00782

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