Article
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice.
Cancer research - 1 Jan 2003
Fong Louise Y Y, Ishii Hideshi, Nguyen Vu T, Vecchione Andrea, Farber John L, Croce Carlo M, Huebner Kay
Abstract excerpt
The p53 tumor suppressor protein plays a pivotal role in preventing uncontrolled cellular proliferation. By contrast, zinc deprivation enhances esophageal cell proliferation and the induction of esophageal tumors in rodents by N-nitrosomethylbenzylamine (NMBA). We investigated whether p53 deficiency rendered zinc-deficient (ZD) mice more susceptible to NMBA-induced esophageal/forestomach carcinogenesis. At 6-7...
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