Article
Growth hormone-releasing hormone and pituitary somatotrope proliferation.
Minerva endocrinologica - 1 Dec 2002
Frohman L A, Kineman R D
Abstract excerpt
Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH secretion and/or action result in dysregulated somatotrope proliferation, leading to hyperplasia...
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