Article
The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling.
Endocrinology - 1 Sept 2001
Kineman R D, Teixeira L T, Amargo G V, Coschigano K T, Kopchick J J, Frohman L A
Abstract excerpt
Excessive GHRH stimulation leads to somatotrope hyperplasia and, ultimately, pituitary adenoma formation in the metallothionein promoter-driven human GHRH (hGHRH) transgenic mouse. This pituitary phenotype is similar to that observed in humans with ectopic production of GHRH. In both mice and man, GHRH hyperstimulation also results in dramatic increases in circulating GH and IGF-I. To determine whether GH/IGF-I...
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