Article
Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours.
International journal of molecular sciences - 22 Jan 2021
Mirczuk Samantha M, Scudder Christopher J, Read Jordan E, Crossley Victoria J, Regan Jacob T, Richardson Karen M, Simbi Bigboy, McArdle Craig A, Church David B, Fenn Joseph, Kenny Patrick J, Volk Holger A, Wheeler-Jones Caroline P, Korbonits Márta, Niessen Stijn J, McGonnell Imelda M, Fowkes Robert C
Abstract excerpt
Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mutations cause skeletal overgrowth. Although most of the effects of CNP/GC-B on growth are mediated directly on bone, evidence suggests the natriuretic peptides may...
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