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Article

Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.

PloS one - 1 Jan 2011

Naidu Mamta D, Agarwal Rakhi, Pena Louis A, Cunha Luis, Mezei Mihaly, Shen Min, Wilson David M, Liu Yuan, Sanchez Zina, Chaudhary Pankaj, Wilson Samuel H, Waring Michael J

Abstract excerpt

Lucanthone and hycanthone are thioxanthenone DNA intercalators used in the 1980s as antitumor agents. Lucanthone is in Phase I clinical trial, whereas hycanthone was pulled out of Phase II trials. Their potential mechanism of action includes DNA intercalation, inhibition of nucleic acid biosyntheses, and inhibition of enzymes like topoisomerases and the dual function base excision repair enzyme apurinic...

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Identifiers

PMID: 21935361
DOI: 10.1371/journal.pone.0023679
PMCID: PMC3174134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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