Article
Mcm1p-induced DNA bending regulates the formation of ternary transcription factor complexes.
Molecular and cellular biology - 1 Jan 2003
Lim Fei-Ling, Hayes Andrew, West Adam G, Pic-Taylor Aline, Darieva Zoulfia, Morgan Brian A, Oliver Stephen G, Sharrocks Andrew D
Abstract excerpt
The yeast MADS-box transcription factor Mcm1p plays an important regulatory role in several diverse cellular processes. In common with a subset of other MADS-box transcription factors, Mcm1p elicits substantial DNA bending. However, the role of protein-induced bending by MADS-box proteins in eukaryotic gene regulation is not understood. Here, we demonstrate an important role for Mcm1p-mediated DNA bending in...
Topics
- Alleles
- Base Sequence
- Binding Sites
- Cell Division
- Cell Nucleus
- DNA
- Fungal Proteins
- Genes, Reporter
- Glutathione Transferase
- Minichromosome Maintenance 1 Protein
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed