Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.

doi:10.1074/jbc.M113.508812

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Article

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.

The Journal of biological chemistry - 29 Nov 2013

Quazi Faraz, Molday Robert S

Abstract excerpt

ABCA1, ABCA7, and ABCA4 are members of the ABCA subfamily of ATP-binding cassette transporters that share extensive sequence and structural similarity. Mutations in ABCA1 cause Tangier disease characterized by defective cholesterol homeostasis and high density lipoprotein (HDL) deficiency. Mutations in ABCA4 are responsible for Stargardt disease, a degenerative disorder associated with severe loss in central...

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Topics

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Share to ATP Binding Cassette Transporter 1
Share to Lipoproteins, HDL
Share to Phosphatidylcholines
Share to Phosphatidylethanolamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylserines

Share to Sphingomyelins

Share to Stargardt Disease

Share to Tangier Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 24097981
DOI: 10.1074/jbc.M113.508812
PMCID: PMC3843056

Genes

ABCA1
ABCA4
ABCA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.