Article
Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles.
Biochemical and biophysical research communications - 5 Nov 2004
Nagata Koh, Yamamoto Akitsugu, Ban Nobuhiro, Tanaka Arowu R, Matsuo Michinori, Kioka Noriyuki, Inagaki Nobuya, Ueda Kazumitsu
Abstract excerpt
ABCA3 is highly expressed at the membrane of lamellar bodies in alveolar type II cells, in which pulmonary surfactant is stored. ABCA3 gene mutations cause fatal surfactant deficiency in newborns. We established HEK293 cells stably expressing human ABCA3 and analyzed the function. Exogenously exp...
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