Role of ABC transporters in lipid transport and human disease.

doi:10.1016/j.tem.2013.01.006

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Article

Role of ABC transporters in lipid transport and human disease.

Trends in endocrinology and metabolism: TEM - 1 Jul 2013

Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Edwards Peter A

Abstract excerpt

Almost half of the 48 human ATP-binding cassette (ABC) transporter proteins are thought to facilitate the ATP-dependent translocation of lipids or lipid-related compounds. Such substrates include cholesterol, plant sterols, bile acids, phospholipids, and sphingolipids. Mutations in a substantial number of the 48 human ABC transporters have been linked to human disease. Indeed the finding that 12 diseases have...

Topics

ATP-Binding Cassette Transporters
Animals
Biological Transport
Genetic Diseases, Inborn
Homeostasis
Humans
Lipid Metabolism
Lipid Metabolism Disorders
Models, Biological
Mutation

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Identifiers

PMID: 23415156
DOI: 10.1016/j.tem.2013.01.006
PMCID: PMC3659191

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