Article
Genetic epidemiology of single-nucleotide polymorphisms.
Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 1999
Collins A, Lonjou C, Morton N E
Abstract excerpt
On the causal hypothesis, most genetic determinants of disease are single-nucleotide polymorphisms (SNPs) that are likely to be selected as markers for positional cloning. On the proximity hypothesis, most disease determinants will not be included among markers but may be detected through linkage disequilibrium with other SNPs. In that event, allelic association among SNPs is an essential factor in positional...
Topics
- Case-Control Studies
- Chromosome Mapping
- Cloning, Molecular
- Evolution, Molecular
- Gene Frequency
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium
- Polymorphism, Restriction Fragment Length