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Article

Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments.

Human molecular genetics - 15 Jun 2015

Goorden Susanna M I, Abs Elisabeth, Bruinsma Caroline F, Riemslagh Fréderike W, van Woerden Geeske M, Elgersma Ype

Abstract excerpt

Target of rapamycin complex 1 (TORC1) is an important regulator of neuronal function. However, whereas a modest activation of the TORC1 signaling pathway has been shown to affect synaptic plasticity, learning and memory, the effect of TORC1 hypo-activation is less clear. This knowledge is particu...

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Source

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PMID: 25759467
DOI: 10.1093/hmg/ddv087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25759467-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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