Article
Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
Diabetes - 1 Jan 2003
Poulsen Pernille, Andersen Gitte, Fenger Mogens, Hansen Torben, Echwald Søren M, Vølund Aage, Beck-Nielsen Henning, Pedersen Oluf, Vaag Allan
Abstract excerpt
The Pro12Ala polymorphism in the PPARgamma2 gene has been associated with reduced risk of type 2 diabetes and insulin resistance. Recently, an association between dizygotic twinning and PPARgamma gene polymorphisms has been proposed. We investigated the phenotypic appearance of the two polymorphisms (Pro12Ala and exon 6 C-->T) in PPARgamma among elderly twins (207 monozygotic [MZ] and 342 dizygotic [DZ]) and...
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