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Article

The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes.

Biochemical and biophysical research communications - 29 Apr 2000

Hara K, Okada T, Tobe K, Yasuda K, Mori Y, Kadowaki H, Hagura R, Akanuma Y, Kimura S, Ito C, Kadowaki T

Abstract excerpt

Peroxisome proliferator-activated receptor gamma (PPARgamma) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPARgamma led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPARgamma2 gene. Since this amino acid substitution may cause a reduction in the...

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Identifiers

PMID: 10777704
DOI: 10.1006/bbrc.2000.2605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes.PMID 10777704Read ↗

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