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Article

DNA Modifications by a Novel Bifunctional Trinuclear Platinum Phase I Anticancer Agent

1 May 1999

Abstract excerpt

The DNA-binding profile of a novel, trinuclear platinum Phase I clinical agent (BBR3464) is summarized. The structure of BBR3464 is best described as two trans-[PtCl(NH3)2] units linked by a tetra-amine [trans-Pt(NH3)2{H2N(CH2)6NH2}2]2+ unit. The +4 charge of BBR3464, the presence of at least two Pt coordination units capable of binding to DNA, and the consequences of such DNA binding are remarkable departures...

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PMID: 10346899
DOI: 10.1021/bi990124s

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