Article
Genetic analysis of hMLH1 in transitional cell carcinoma of the urinary tract: promoter methylation or mutation.
The Journal of urology - 1 May 2001
Furihata M, Takeuchi T, Ohtsuki Y, Terao N, Kuwahara M, Shuin T
Abstract excerpt
PURPOSE: Loss of DNA mismatch repair due to diminished expression or mutation of hMLH1 is associated with genomic instability followed by cancer. We performed genetic analyses of hMLH1 to determine whether hMLH1 alterations have a role in urothelial tumorigenesis. MATERIALS AND METHODS: We examined genomic DNA from 118 sporadic transitional cell carcinomas, including 83 bladder and 35 renal pelvis or ureter...
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