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Mismatch repair gene expression and genetic instability in testicular germ cell tumor

1 Oct 2004

Abstract excerpt

Human mismatch repair (MMR) genes encode highly conserved interacting proteins that correct replication errors predisposing to hereditary gastrointestinal and genitourinary malignancies. A subset of sporadic genitourinary tumors also exhibits MMR deficiency and can be identified by measuring the frequency of microsatellite instability (MSI) in cancer cell DNA. We investigated expression of the two most commonly...

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PMID: 15467433
DOI: 10.4161/cbt.3.10.1135

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