Article
Extensive somatic microsatellite mutations in normal human tissue.
Cancer research - 1 Jun 2001
Vilkki S, Tsao J L, Loukola A, Pöyhönen M, Vierimaa O, Herva R, Aaltonen L A, Shibata D
Abstract excerpt
Microsatellite (MS) instability occurs in tumors with DNA mismatch repair (MMR) deficiencies but is typically absent in adjacent normal tissue. However, MS mutations have been observed in normal tissues from rare individuals with congenital MMR deficiencies. Autopsy tissues from a 4-year-old with congenital MMR deficiency (MLH1-/-) were examined for MS mutations. Insertions and deletions were observed in...
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