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Article

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span.

The Journal of biological chemistry - 23 Apr 2004

Martin-Ruiz Carmen, Saretzki Gabriele, Petrie Joanne, Ladhoff Juliane, Jeyapalan Jessie, Wei Wenyi, Sedivy John, von Zglinicki Thomas

Abstract excerpt

The replicative life span of human fibroblasts is heterogeneous, with a fraction of cells senescing at every population doubling. To find out whether this heterogeneity is due to premature senescence, i.e. driven by a nontelomeric mechanism, fibroblasts with a senescent phenotype were isolated from growing cultures and clones by flow cytometry. These senescent cells had shorter telomeres than their cycling...

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PMID: 14963037
DOI: 10.1074/jbc.M311980200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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