Article
Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.
Oncotarget - 26 Apr 2016
Sung Hyeran, Kanchi Krishna L, Wang Xue, Hill Kristen S, Messina Jane L, Lee Ji-Hyun, Kim Youngchul, Dees Nathan D, Ding Li, Teer Jamie K, Yang Shengyu, Sarnaik Amod A, Sondak Vernon K, Mulé James J, Wilson Richard K, Weber Jeffrey S, Kim Minjung
Abstract excerpt
Inactivation of Ras GTPase activating proteins (RasGAPs) can activate Ras, increasing the risk for tumor development. Utilizing a melanoma whole genome sequencing (WGS) data from 13 patients, we identified two novel, clustered somatic missense mutations (Y472H and L481F) in RASA1 (RAS p21 protein activator 1, also called p120RasGAP). We have shown that wild type RASA1, but not identified mutants, suppresses soft...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Biomarkers, Tumor
- Cell Proliferation
- Cell Transformation, Neoplastic
- Follow-Up Studies
- Humans
- Melanoma
- Mice