Article
Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease.
Immunological reviews - 1 Dec 2002
Lazarus Ross, Vercelli Donata, Palmer Lyle J, Klimecki Walt J, Silverman Edwin K, Richter Brent, Riva Alberto, Ramoni Marco, Martinez Fernando D, Weiss Scott T, Kwiatkowski David J
Abstract excerpt
Under selective pressure from infectious microorganisms, multicellular organisms have evolved immunological defense mechanisms, broadly categorized as innate or adaptive. Recent insights into the complex mechanisms of human innate immunity suggest that genetic variability in genes encoding its components may play a role in the development of asthma and related diseases. As part of a systematic assessment of...
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