Article
Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease.
The Biochemical journal - 15 May 1999
Chan V J, Selzer P M, McKerrow J H, Sakanari J A
Abstract excerpt
The mature form of the cathepsin B-like protease of Leishmania major (LmajcatB) is a 243 amino acid protein belonging to the papain family of cysteine proteases and is 54% identical to human-liver cathepsin B. Despite the high identity and structural similarity with cathepsin B, LmajcatB does not readily hydrolyse benzyloxycarbonyl-Arg-Arg-7-amino-4-methyl coumarin (Z-Arg-Arg-AMC), which is cleaved by cathepsin B...
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