Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.

Oncology reports - 1 Jun 2012

Dura Polat, Bregitha Caro V V, Te Morsche Rene H M, Roelofs Hennie M J, Kristinsson Jon O, Wobbes Theo, Witteman Ben J M, Tan Adriaan C I T L, Drenth Joost P H, Peters Wilbert H M

Abstract excerpt

Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and exon 4 of the microsomal epoxide hydrolase gene (EPHX1) modify catalytic activity of this enzyme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epoxide Hydrolases

Share to Esophageal Neoplasms

Share to Heterozygote

Share to Homozygote

Share to Netherlands

Share to White People

Source

Identifiers

PMID: 22447130
DOI: 10.3892/or.2012.1734

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.PMID 22447130Read ↗

Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.Semantic proximity Read ↗

Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk.Semantic proximity Read ↗

Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.Semantic proximity Read ↗

Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.Semantic proximity Read ↗

Association between esophageal cancer risk and EPHX1 polymorphisms: a meta-analysis.Semantic proximity Read ↗

Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India.Semantic proximity Read ↗

Association between head and neck cancer and microsomal epoxide hydrolase genotypes.Semantic proximity Read ↗

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis.Semantic proximity Read ↗

High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.Semantic proximity Read ↗

Lack of association of EPHX1 genotypes and haplotypes with oral cancer in South Indians.Semantic proximity Read ↗

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.Semantic proximity Read ↗

Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.