Article
Evaluation of germline sequence variants of GFRA1, GFRA2, and GFRA3 genes in a cohort of Spanish patients with sporadic medullary thyroid cancer.
Thyroid : official journal of the American Thyroid Association - 1 Nov 2002
Borrego Salud, Fernández Raquel M, Dziema Heather, Japón Miguel A, Marcos Irene, Eng Charis, Antiñolo Guillermo
Abstract excerpt
The etiology of sporadic medullary thyroid carcinoma (sMTC) remains elusive. While germline gain-of-function mutations in the RET proto-oncogene cause hereditary MTC, somatic RET mutations have been described in a variable number of sMTC. So far, S836S of RET, is the only variant whose association with sMTC has been found in several European cohorts. Because RET variants seem to be associated with MTC, it is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.