Article
The C terminus of mammalian phospholipase D is required for catalytic activity.
The Journal of biological chemistry - 23 Feb 2001
Liu M Y, Gutowski S, Sternweis P C
Abstract excerpt
The activity of phospholipase D (PLD) is regulated by a variety of hormonal stimuli and provides a mechanistic pathway for response of cells to extracellular stimuli. The two identified mammalian PLD enzymes possess highly homologous C termini, which are required for catalytic activity. Mutational analysis of PLD1 and PLD2 reveals that modification of as little as the C-terminal threonine or the addition of a...
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