Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of DNA repair by mutations flanking the DNA channel through RNA polymerase.

The EMBO journal - 16 Dec 2002

Trautinger Brigitte W, Lloyd Robert G

Abstract excerpt

The RuvABC and RecBCD proteins promote rescue of stalled or broken DNA replication forks in Escherichia coli. Strains lacking these proteins cope poorly with DNA damage and have problems with chromosome segregation and cell division. We show how these difficulties are overcome to varying degrees by a sub-class of RNA polymerase mutations selected for their stringent phenotype. Thirty-five mutations were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed RNA Polymerases
Share to Dose-Response Relationship, Radiation
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microscopy, Phase-Contrast

Share to Rifampin

Share to Thermus

Share to Transcriptional Elongation Factors

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 12486015
DOI: 10.1093/emboj/cdf654
PMCID: PMC139083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of DNA repair by mutations flanking the DNA channel through RNA polymerase.PMID 12486015Read ↗

Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword.Semantic proximity Read ↗

RNA polymerase mutants defective in the initiation of transcription-coupled DNA repair.Semantic proximity Read ↗

Roles of E. coli double-strand-break-repair proteins in stress-induced mutation.Semantic proximity Read ↗

Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase.Semantic proximity Read ↗

UV-induced DNA damage disrupts the coordination between replication initiation, elongation and completion.Semantic proximity Read ↗

The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants.Semantic proximity Read ↗

The nature of mutations induced by replication–transcription collisions.Semantic proximity Read ↗

Role of the two ATPase domains of Escherichia coli UvrA in binding non-bulky DNA lesions and interaction with UvrB.Semantic proximity Read ↗

Replication fork collapse at a protein-DNA roadblock leads to fork reversal, promoted by the RecQ helicaseSemantic proximity Read ↗

A DNA translocation motif in the bacterial transcription--repair coupling factor, Mfd.Semantic proximity Read ↗

Genetic dissection of DNA damage tolerance in Bacillus subtilis: RecA and recombination functions regulate translesion synthesis.Semantic proximity Read ↗

A role for topoisomerase III in a recombination pathway alternative to RuvABC.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.