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Article

Linkage and association studies of single-nucleotide polymorphism-tagged tumor necrosis factor haplotypes in juvenile oligoarthritis.

Arthritis and rheumatism - 1 Dec 2002

Zeggini Eleftheria, Thomson Wendy, Kwiatkowski Dominic, Richardson Anna, Ollier William, Donn Rachelle

Abstract excerpt

OBJECTIVE: The presence of increased levels of tumor necrosis factor (TNF) in serum and synovial fluid of patients and the encouraging outcome of anti-TNF therapy have implicated TNFalpha in the etiopathogenesis of juvenile oligoarthritis. Although the locus is polymorphic, no study has investigated all TNF single-nucleotide polymorphisms (SNPs) with respect to disease. The aim of this study was to examine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12483736
DOI: 10.1002/art.10698

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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