Article
Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone.
Oncotarget - 10 May 2015
Kawabata Shigeru, Hollander M Christine, Munasinghe Jeeva P, Brinster Lauren R, Mercado-Matos José R, Li Jie, Regales Lucia, Pao William, Jänne Pasi A, Wong Kwok-Kin, Butman John A, Lonser Russell R, Hansen Marlan R, Gurgel Richard K, Vortmeyer Alexander O, Dennis Phillip A
Abstract excerpt
Adenomatous tumors in the middle ear and temporal bone are rare but highly morbid because they are difficult to detect prior to the development of audiovestibular dysfunction. Complete resection is often disfiguring and difficult because of location and the late stage at diagnosis, so identification of molecular targets and effective therapies is needed. Here, we describe a new mouse model of aggressive papillary...
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