HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.

doi:10.1073/pnas.0808930106

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Article

HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2009

Perera Samanthi A, Li Danan, Shimamura Takeshi, Raso Maria G, Ji Hongbin, Chen Liang, Borgman Christa L, Zaghlul Sara, Brandstetter Kathleyn A, Kubo Shigeto, Takahashi Masaya, Chirieac Lucian R, Padera Robert F, Bronson Roderick T, Shapiro Geoffrey I, Greulich Heidi, Meyerson Matthew, Guertler Ulrich, Chesa Pilar Garin, Solca Flavio, Wistuba Ignacio I, Wong Kwok-Kin

Abstract excerpt

Mutations in the HER2 kinase domain have been identified in human clinical lung cancer specimens. Here we demonstrate that inducible expression of the most common HER2 mutant (HER2(YVMA)) in mouse lung epithelium causes invasive adenosquamous carcinomas restricted to proximal and distal bronchioles. Continuous expression of HER2(YVMA) is essential for tumor maintenance, suggesting a key role for HER2 in lung...

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PMID: 19122144
DOI: 10.1073/pnas.0808930106
PMCID: PMC2626727

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