Article
Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice.
Nature neuroscience - 1 Jan 2003
Anagnostaras Stephan G, Murphy Geoffrey G, Hamilton Susan E, Mitchell Scott L, Rahnama Nancy P, Nathanson Neil M, Silva Alcino J
Abstract excerpt
Blockade of cholinergic neurotransmission by muscarinic receptor antagonists produces profound deficits in attention and memory. However, the antagonists used in previous studies bind to more than one of the five muscarinic receptor subtypes. Here we examined memory in mice with a null mutation of the gene coding the M1 receptor, the most densely distributed muscarinic receptor in the hippocampus and forebrain....
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