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Article

Enhanced detection of mutations in BRCA1 exon 11 using restriction endonuclease fingerprinting-single-strand conformation polymorphism.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2000

Jugessur A, Frost P, Andersen T I, Steine S, Lindblom A, Børresen-Dale A L, Eiken H G

Abstract excerpt

A novel approach to mutation screening in the large exon 11 (comprising 3427 bp) of the human BRCA1 gene is presented. Restriction endonuclease fingerprinting single-strand conformation polymorphism (REF-SSCP) is based on repeated detection of DNA sequence variants in different restriction endonuclease fragments, and we evaluated the method using blood samples from 25 Norwegian patients with hereditary...

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Source

Identifiers

PMID: 11199332
DOI: 10.1007/s001090000147

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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