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Article

A fluorescent multiplex-DGGE screening test for mutations in the BRCA1 gene.

Genetic testing - 1 Jan 2006

Kuperstein Graciela, Jack Elaine, Narod Steven A

Abstract excerpt

Screening for mutations in the BRCA1 gene is challenging because of the wide spectrum of mutations found in this large gene. As the extensive exon 11 is commonly screened by the protein truncation test (PTT), here a fluorescent multiplex denaturing gradient gel electrophoresis (FMD) mutation screening technique was developed to test the remaining numerous small exons and splice sites of the gene. The method is...

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Source

Identifiers

PMID: 16544996
DOI: 10.1089/gte.2006.10.1

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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