Article
Fluorescence-based single-strand conformation polymorphism analysis of mutations by capillary electrophoresis.
Electrophoresis - 1 Jan 2000
Walz T, Geisel J, Bodis M, Knapp J P, Herrmann W
Abstract excerpt
Capillary electrophoresis in combination with fluorescence-based single-strand conformation polymorphism (SSCP) analysis was used to screen for known mutations as well as for unknown mutations. The mutations causing hemochromatosis and thrombogenetic diseases (factor V Leiden mutation and prothrombin mutation) are well defined. Familial hypercholesterolemia is caused by mutations in the low density lipoprotein...
Topics
- Animals
- DNA
- Electrophoresis, Capillary
- Fluorescent Dyes
- Humans
- Mutation
- Polymorphism, Single-Stranded Conformational