Article

In Silico Restriction Mapping of BRCA1, BRCA2, TP53, and ERBB2 Variants for Identification of Potential PCR-RFLP Diagnostic Markers in Breast Cancer

2026-06-05

Abstract excerpt

<title>Abstract</title> <p> Breast cancer-associated genes ( <italic>BRCA1</italic> , <italic>BRCA2</italic> , <italic>TP53</italic> , and <italic>ERBB2</italic> ) harbor pathogenic variants that contribute to tumor development and may alter restriction enzyme recognition sites. This study performed a comparative in silico restriction mapping of wild-type and mutant sequences to identify mutation-associa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fcc2c53-5dde-5b0c-ad6e-fe45b0d0fbaf
DOI: 10.21203/rs.3.rs-9918168/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In Silico Restriction Mapping of BRCA1, BRCA2, TP53, and ERBB2 Variants for Identification of Potential PCR-RFLP Diagnostic Markers in Breast CancerDOI 10.21203/rs.3.rs-9918168/v1Read

Domain-specific Analysis of BRCA1 Variants Revealed Enrichment of G → T and C → A TransversionsSemantic proximity Read

Discovery of structural deletions in breast cancer susceptibility genes using whole genome sequencing data from >2,000 African ancestry womenSemantic proximity Read

Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysis.Semantic proximity Read

Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysisSemantic proximity Read

Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer.Semantic proximity Read

Diagnostic accuracy of methods for the detection of BRCA1 and BRCA2 mutations: a systematic review.Semantic proximity Read

Development of diagnostic SCAR markers for genomic DNA amplifications in breast carcinoma by DNA cloning of high-GC RAMP-PCR fragmentsSemantic proximity Read

Detection of hotspot mutations and polymorphisms using an enhanced PCR-RFLP approach.Semantic proximity Read

Restriction enzyme analysis of PCR products.Semantic proximity Read

Analysis of BRIP1 Variants among Korean Patients with BRCA1/2 Mutation-Negative High-Risk Breast Cancer.Semantic proximity Read

BRCA1 and BRCA2 screening of nine Chilean founder mutations through allelic-discrimination and real-time PCR in breast/ovarian cancer patients.Semantic proximity Read

BRCA1 mutation screening using restriction endonuclease fingerprinting-single-strand conformation polymorphism in an automated capillary electrophoresis system.Semantic proximity Read