Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.

doi:10.1038/ncomms4904

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Article

Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.

Nature communications - 2 Jun 2014

Green Michael R, Vicente-Dueñas Carolina, Romero-Camarero Isabel, Long Liu Chih, Dai Bo, González-Herrero Inés, García-Ramírez Idoia, Alonso-Escudero Esther, Iqbal Javeed, Chan Wing C, Campos-Sanchez Elena, Orfao Alberto, Pintado Belén, Flores Teresa, Blanco Oscar, Jiménez Rafael, Martínez-Climent Jose Angel, Criado Francisco Javier García, Cenador María Begoña García, Zhao Shuchun, Natkunam Yasodha, Lossos Izidore S, Majeti Ravindra, Melnick Ari, Cobaleda César, Alizadeh Ash A, Sánchez-García Isidro

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma and can be separated into two subtypes based upon molecular features with similarities to germinal centre B-cells (GCB-like) or activated B-cells (ABC-like). Here we identify gain of 3q27.2 as being significantly associated with adverse outcome in DLBCL and linked with the ABC-like subtype. This lesion includes the BCL6 oncogene, but does not alter...

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Identifiers

PMID: 24887457
DOI: 10.1038/ncomms4904
PMCID: PMC4321731

Genes

BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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