Article
Targeted gene disruption reveals a role for vacuolin B in the late endocytic pathway and exocytosis.
Journal of cell science - 1 Jan 1998
Jenne N, Rauchenberger R, Hacker U, Kast T, Maniak M
Abstract excerpt
Cells of Dictyostelium discoideum take up fluid by macropinocytosis. The contents of macropinosomes are acidified and digested by lysosomal enzymes. Thereafter, an endocytic marker progresses in an F-actin dependent mechanism from the acidic lysosomal phase to a neutral post-lysosomal phase. From the post-lysosomal compartment indigestible remnants are released by exocytosis. This compartment is characterised by...
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