Article
Phg1p is a nine-transmembrane protein superfamily member involved in dictyostelium adhesion and phagocytosis.
The Journal of biological chemistry - 3 Nov 2000
Cornillon S, Pech E, Benghezal M, Ravanel K, Gaynor E, Letourneur F, Brückert F, Cosson P
Abstract excerpt
To identify the molecular mechanisms involved in phagocytosis, we generated random insertion mutants of Dictyostelium discoideum and selected two mutants defective for phagocytosis. Both represented insertions in the same gene, named PHG1. This gene encodes a polytopic membrane protein with an N-terminal lumenal domain and nine potential transmembrane segments. Homologous genes can be identified in many species;...
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