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Proinsulin 2 knockout NOD mice: a model for genetic variation of insulin gene expression in type 1 diabetes.

Diabetes - 1 Dec 2002

Dubois-Lafforgue Danièle, Mogenet Laurent, Thébault Karine, Jami Jacques, Krief Patricia, Boitard Christian

Abstract excerpt

Insulin is a major disease determinant in type 1 diabetes, type 2 diabetes, and related disorders. The role of variations in the expression of the insulin gene has been proposed in genetic susceptibility to the three pathological conditions in humans. In contrast to humans, rodents express two proinsulin isoforms. One isoform, proinsulin 1, is expressed exclusively in islets. The second, proinsulin 2, is...

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Identifiers

PMID: 12475795
DOI: 10.2337/diabetes.51.2007.s489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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