Article
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes.
Nature immunology - 1 Oct 2004
Jaeckel Elmar, Lipes Myra A, von Boehmer Harald
Abstract excerpt
Although autoimmune diseases can be initiated by immunization with a single antigen, it is not clear whether a single self antigen is essential for the initiation and, perhaps, the perpetuation of spontaneous autoimmunity. Some studies have suggested that insulin may represent an essential autoantigen in type 1 diabetes. Here we show that unlike tolerance to glutamic acid decarboxylase, tolerance to...
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