Article
Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene.
Annals of the New York Academy of Sciences - 1 Dec 2004
Nakayama Maki, Moriyama Hiroaki, Abiru Norio, Babu Sunanda R, Sikora Kamila, Li Marcella, Miao Dongmei, Hutton John C, Elliott John F, Eisenbarth George S
Abstract excerpt
We hypothesize that NOD mice without native insulin, but with an altered insulin B:9-23 sequence, will be completely protected from diabetes/insulitis if insulin B:9-23 is an essential T cell epitope. To investigate this hypothesis, we have established initial insulin 1- and 2-negative NOD mice with a transgene directing production of preproinsulin with alanine at position B:16 rather than the native tyrosine of...
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