Comparative gene array analyses of severe elastic fiber defects in late embryonic and newborn mouse aorta

Abstract excerpt

Elastic fibers provide reversible elasticity to the large arteries and are assembled during development when hemodynamic forces are increasing. Mutations in elastic fiber genes are associated with cardiovascular disease. Mice lacking expression of the elastic fiber genes elastin ( Eln−/−), fibulin-4 ( Efemp2−/−), or lysyl oxidase ( Lox−/−) die at birth with severe cardiovascular malformations. All three genetic...

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