Article
The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma.
Carcinogenesis - 1 Dec 2004
Zhang Jianhui, Jin Xia, Fang Shumei, Li Yan, Wang Rui, Guo Wei, Wang Na, Wang Yimin, Wen Denggui, Wei Lizhen, Kuang Gang, Dong Zhiming
Abstract excerpt
The matrix metalloproteinases (MMPs), a family of proteolytic enzymes that degrade different components of the extracellular matrix, play important roles in tumor development and invasion. A single adenine insertion/deletion polymorphism (6A/5A) in the MMP3 promoter region causes transcriptional...
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