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MMP1 and MMP3 Polymorphisms in Promoter Regions and Cancer

1 Dec 2000

Abstract excerpt

Tumors spread by way of a multistep process in which degradation of the extracellular matrix and basement membrane barriers is a key feature. The matrix metalloproteinases (MMPs) comprise a family of at least 16 proteolytic enzymes that degrade the extracellular matrix in a substrate-specific manner and are thought to have important roles in tumor invasion and metastasis (1). Overexpression of MMPs is associated...

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PMID: 11106348
DOI: 10.1093/clinchem/46.12.2023

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